CENPU and PLK2

Data Source:
BioGRID (unspecified method)

		CENPU	PLK2
Description		centromere protein U	polo like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite	Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Dendrite
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Protein Binding Protein-containing Complex Binding
	Biological Process	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Dendritic Spine Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response
Drugs			Fostamatinib
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)
Interacting Genes		17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	10 interacting genes: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA TSC1 TSC2
Entrez ID		79682	10769
HPRD ID		14722	06118
Ensembl ID		ENSG00000151725	ENSG00000145632
Uniprot IDs		Q71F23	A0A024QZV1 A0A087WUH9 Q9NYY3
PDB IDs			4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?
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