PLK2 and MPP3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLK2	MPP3
Description		polo like kinase 2	membrane palmitoylated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Dendrite
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Dendritic Spine Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response
Drugs		Fostamatinib
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)	HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068)
Interacting Genes		10 interacting genes: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA TSC1 TSC2	39 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A LIN7B LIN7C MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1
Entrez ID		10769	4356
HPRD ID		06118	03069
Ensembl ID		ENSG00000145632	ENSG00000161647
Uniprot IDs		A0A024QZV1 A0A087WUH9 Q9NYY3	D3DX46 Q13368
PDB IDs		4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?
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