PLK2 and CDC20B

Data Source:
BioGRID (two hybrid)

		PLK2	CDC20B
Description		polo like kinase 2	cell division cycle 20B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Dendrite	Anaphase-promoting Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding ATP-dependent Protein Binding Protein-containing Complex Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Dendritic Spine Development Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence	Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response
Drugs		Fostamatinib
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)	Cocaine dependence ( 31212010)
Interacting Genes		10 interacting genes: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA TSC1 TSC2	21 interacting genes: CCDC57 FHL5 GEMIN4 GOLGA2 KANK2 KRT31 KRT34 KRT40 MAGEA11 MDFI MTUS2 NUTM1 PLEKHF2 PLK2 SPAG5 TACC3 TRAF2 TRIM23 TRIM27 TRIM37 VPS52
Entrez ID		10769	166979
HPRD ID		06118	13428
Ensembl ID		ENSG00000145632	ENSG00000164287
Uniprot IDs		A0A024QZV1 A0A087WUH9 Q9NYY3	Q86Y33
PDB IDs		4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?
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