UBE2G2 and KDM2A

Data Source:
BioGRID (two hybrid)

		UBE2G2	KDM2A
Description		ubiquitin conjugating enzyme E2 G2	lysine demethylase 2A
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II Protein Demethylation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Histone H3-K36 Demethylation
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	HDMs demethylate histones
Drugs
Diseases
GWAS			Height ( 28552196 28270201) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 32888494 27863252)
Interacting Genes		39 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	11 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B
Entrez ID		7327	22992
HPRD ID		04387	05741
Ensembl ID		ENSG00000184787	ENSG00000173120
Uniprot IDs		P60604	I3VM53 I3VM54 Q9Y2K7
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD	2YU1 2YU2 4BBQ 6BYH 6C16
Enriched GO Terms of Interacting Partners?
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