KDM2A and FBXO32

Data Source:
BioGRID (two hybrid)

		KDM2A	FBXO32
Description		lysine demethylase 2A	F-box protein 32
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)	Protein Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II Protein Demethylation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Histone H3-K36 Demethylation	Protein Polyubiquitination Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Post-translational Protein Modification Cellular Response To Dexamethasone Stimulus
Pathways		HDMs demethylate histones	Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 28552196 28270201) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 32888494 27863252)	Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998 29785010 31959993 30054594) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		11 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B	10 interacting genes: CDC34 EIF3F KDM2A MLH1 MYOD1 MYOG SH3GL1 SH3GL2 SH3GL3 SKP1
Entrez ID		22992	114907
HPRD ID		05741	05966
Ensembl ID		ENSG00000173120	ENSG00000156804
Uniprot IDs		I3VM53 I3VM54 Q9Y2K7	A0A024R9F3 I6L984 Q0VAQ6 Q498Y9 Q969P5
PDB IDs		2YU1 2YU2 4BBQ 6BYH 6C16
Enriched GO Terms of Interacting Partners?
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