KDM2A and SMAD7

Data Source:
HPRD (two hybrid)

		KDM2A	SMAD7
Description		lysine demethylase 2A	SMAD family member 7
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GO Annotations	Cellular Component	Nucleoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Catenin Complex Protein-containing Complex Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)	DNA Binding Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding Activin Binding I-SMAD Binding Transcription Regulator Inhibitor Activity
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription By RNA Polymerase II Protein Demethylation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Histone H3-K36 Demethylation	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein-containing Complex Localization Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		HDMs demethylate histones	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Height ( 28552196 28270201) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 32888494 27863252)	Asthma ( 32296059) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 25990418 18372901 18372905 30529582 21761138 17934461 26151821 29228715 30104761 24836286 29471430 24448986 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252)
Interacting Genes		11 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B	59 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L OTUD1 PARD3 PIAS1 PIAS4 RLIM RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107
Entrez ID		22992	4092
HPRD ID		05741	04241
Ensembl ID		ENSG00000173120	ENSG00000101665
Uniprot IDs		I3VM53 I3VM54 Q9Y2K7	B3KYA8 O15105
PDB IDs		2YU1 2YU2 4BBQ 6BYH 6C16	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?
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