UBE2G2 and CPOX

Data Source:
BioGRID (two hybrid)

		UBE2G2	CPOX
Description		ubiquitin conjugating enzyme E2 G2	coproporphyrinogen oxidase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity	Coproporphyrinogen Oxidase Activity Protein Homodimerization Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Heme biosynthesis
Drugs
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS			Refractive error ( 32231278)
Interacting Genes		39 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4	1 interacting genes: UBE2G2
Entrez ID		7327	1371
HPRD ID		04387	00417
Ensembl ID		ENSG00000184787	ENSG00000080819
Uniprot IDs		P60604	P36551
PDB IDs		2CYX 2KLY 2LXP 3H8K 4LAD	2AEX
Enriched GO Terms of Interacting Partners?
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