ENO1 and PAF1

Data Source:
BioGRID (two hybrid)

		ENO1	PAF1
Description		enolase 1	PAF1 homolog, Paf1/RNA polymerase II complex component
Image
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane M Band Extracellular Exosome Cell Cortex Region	Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex Cell Junction Transcriptionally Active Chromatin
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Protein Homodimerization Activity Cadherin Binding GTPase Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Regulation Of Vacuole Fusion, Non-autophagic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Nucleosome Positioning Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of MRNA 3'-end Processing Histone H2B Ubiquitination Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		59 interacting genes: AGTPBP1 ALDOA AMBP ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CLK1 COL14A1 CYSLTR2 DES DUX4 FANCA FHL1 FLNC FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPA8 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 P4HB PAF1 PCNA PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TRAPPC2 TTN UPF2 YWHAQ YWHAZ ZBTB44	17 interacting genes: ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A LEO1 MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3
Entrez ID		2023	54623
HPRD ID		01400	10140
Ensembl ID		ENSG00000074800	ENSG00000006712
Uniprot IDs		A0A024R4F1 P06733	A0A024R0H6 Q8N7H5
PDB IDs		2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK	4M6T 5ZYQ 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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