TLE1 and PRDM1

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TLE1	PRDM1
Description		TLE family member 1, transcriptional corepressor	PR/SET domain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Innate Immune Response Cell Fate Commitment Regulation Of NK T Cell Differentiation
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Regulation of TP53 Expression
Drugs
Diseases
GWAS		Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 32499647 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)
Interacting Genes		84 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64	10 interacting genes: ATXN1 H1-1 H3C15 IKZF3 IRF4 KDM1A PIAS1 TLE1 TLE2 TLE5
Entrez ID		7088	639
HPRD ID		02557	04572
Ensembl ID		ENSG00000196781	ENSG00000057657
Uniprot IDs		B4DEF9 Q04724 Q59EF7	A0A3B3IU23 B4DW27 O75626 Q5T4E8
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ	3DAL
Enriched GO Terms of Interacting Partners?
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