TLE1 and HLA-DQA1

Data Source:
HPRD (two hybrid)

		TLE1	HLA-DQA1
Description		TLE family member 1, transcriptional corepressor	major histocompatibility complex, class II, DQ alpha 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases			Type I diabetes mellitus Dilated cardiomyopathy (DCM) Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 32499647 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Adult asthma ( 30578877) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 32737300) Anti-polyomavirus 2 IgG seropositivity ( 33204752) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Apolipoprotein B levels ( 32203549) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474 29273806 23181788) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basal cell carcinoma ( 31174203) Blood protein levels ( 29875488) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 27182965 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 21131588) Chronic rhinosinusitis ( 30643255) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Cutaneous lupus erythematosus ( 25827949) Cutaneous squamous cell carcinoma ( 32041948) Drug-induced liver injury (flucloxacillin) ( 30661239) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Epstein-Barr virus immune response (multivariate analysis) ( 29868224) Epstein-Barr virus VCA p18 antibody levels ( 33204752) Epstein-Barr virus ZEBRA antibody levels ( 33204752) Estimated glomerular filtration rate ( 30604766) Factor VIII levels ( 30586737) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Hepatocellular carcinoma ( 22807686) Herpes simplex virus 6 IE1B antibody levels ( 33204752) Herpes simplex virus 7 U14 antibody levels ( 33204752) High density lipoprotein cholesterol levels ( 29403010) Hypothyroidism ( 27182965 22493691) Idiopathic membranous nephropathy ( 21323541) IgA nephropathy ( 26028593 25305756) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A vasculitis ( 28698626) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28008999 18758464 28067908) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Leprosy ( 32421744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lymphocyte counts ( 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Lymphoma ( 23349640) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Membranous nephropathy ( 27333618) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nasal polyps ( 30643255) Nephropathy ( 21399633) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Oligoclonal band status in multiple sclerosis ( 25616667) Oropharynx cancer ( 32276964) Parental lifespan ( 30642433 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 27182965 28892059) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 23918589) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 23212062 19571809) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203 26829030) Squamous cell lung carcinoma ( 28604730) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 18204098 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549) Tuberculosis ( 28928442) Type 2 diabetes ( 28566273) Ulcerative colitis ( 28008999 24837172 28067908 26278503 23128233 21297633 19122664 23511034) Urate levels ( 31578528) Varicella zoster virus glycoproteins E and I antibody levels ( 33204752) Vitiligo ( 20410501 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386) White blood cell count ( 32888494)
Interacting Genes		84 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64	9 interacting genes: APLP1 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119
Entrez ID		7088	3117
HPRD ID		02557	06765
Ensembl ID		ENSG00000196781	ENSG00000196735
Uniprot IDs		B4DEF9 Q04724 Q59EF7	A0A173ADG5 P01909 Q8MH44
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ	1JK8 1NBN 1S9V 1UVQ 2NNA 3PL6 4GG6 4OZF 4OZG 4OZH 4OZI 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG 6U3M 6U3N
Enriched GO Terms of Interacting Partners?
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