TLE1 and DLEU1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TLE1	DLEU1
Description		TLE family member 1, transcriptional corepressor	deleted in lymphocytic leukemia 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding
	Biological Process	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 32499647 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)	Adiponectin levels ( 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Aluminium levels ( 26025379) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163) Circulating odd-numbered chain saturated fatty acid levels (C19:0) ( 29738550) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) FEV1 ( 30804560) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340 31217584) Hematocrit ( 29403010 32888494) Hemoglobin ( 29403010 32888494) Hip circumference adjusted for BMI ( 28552196) Lipoprotein (a) levels ( 30108283) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21833088 27386562) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Plasma anti-thyroid peroxidase levels ( 29678681) Platelet distribution width ( 32888494) Primary biliary cholangitis ( 26394269) Prostate-specific antigen levels ( 28139693) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tumor necrosis factor alpha levels ( 31217265) Type 2 diabetes ( 30054458 30297969 32499647) Urinary albumin-to-creatinine ratio ( 31630189) Urinary magnesium excretion ( 31993563) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		84 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64	20 interacting genes: ABCD4 ABCF3 ARL8B CCDC90B CEP126 COPS6 EEF1A1 EEF1G GDF9 GOPC KAT5 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A
Entrez ID		7088	10301
HPRD ID		02557	16150
Ensembl ID		ENSG00000196781	ENSG00000176124
Uniprot IDs		B4DEF9 Q04724 Q59EF7
PDB IDs		1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?
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