TLE1 and ARL3

  • Data Source:
  • HPRD (two hybrid)

TLE1

ARL3

Description TLE family member 1, transcriptional corepressor ADP ribosylation factor like GTPase 3
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Blood protein levels ( 30072576)
  • Brain morphology (MOSTest) ( 32665545)
  • Diastolic blood pressure ( 30487518)
  • Mean arterial pressure ( 30487518)
  • Mean arterial pressure (long-term average) ( 28348047)
  • Prostate cancer ( 23535732)
  • Pulse pressure ( 30487518)
  • Refractive error ( 32231278)
  • Schizophrenia ( 28991256 25056061 27922604)
  • Systolic blood pressure ( 30487518)
  • Systolic blood pressure (long-term average) ( 28348047)
  • Waist-to-hip ratio adjusted for BMI ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes 84 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64 11 interacting genes: ARL2BP GOLGA4 LRIF1 PDE6D RP2 TBL1X TLE1 TP53 TUBA1A UBR1 UNC119
Entrez ID 7088 403
HPRD ID 02557 05260
Ensembl ID ENSG00000196781 ENSG00000138175
Uniprot IDs B4DEF9 Q04724 Q59EF7 P36405
PDB IDs 1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?
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