ABCC8 and ENSA

Data Source:
HPRD (in vivo)

		ABCC8	ENSA
Description		ATP binding cassette subfamily C member 8	endosulfine alpha
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex	Nucleoplasm Cytoplasm
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Phosphatase Inhibitor Activity Potassium Channel Inhibitor Activity Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Nutrient Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Dephosphorylation Regulation Of Insulin Secretion Cell Division
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382)	Albumin-globulin ratio ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Mean corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Morning person ( 30696823) Neutrophil percentage of granulocytes ( 27863252) Non-albumin protein levels ( 29403010) Pericardial adipose tissue adjusted for height and weight ( 27918534) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	10 interacting genes: ABCC8 ACD ARIH2 ENO2 KCTD15 POT1 PSEN1 RAP2A SNCA SRPK2
Entrez ID		6833	2029
HPRD ID		02741	11927
Ensembl ID		ENSG00000006071	ENSG00000143420
Uniprot IDs		Q09428	O43768
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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