ABCC8

Description		ATP binding cassette subfamily C member 8
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GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding
	Biological Process	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		6833
HPRD ID		02741
Ensembl ID		ENSG00000006071
Uniprot IDs		Q09428
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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