ABCC8 and CRYBB1

Data Source:
HPRD (in vivo)

		ABCC8	CRYBB1
Description		ATP binding cassette subfamily C member 8	crystallin beta B1
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GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding	Structural Constituent Of Eye Lens Protein Binding
	Biological Process	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport	Lens Development In Camera-type Eye Visual Perception
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382)	Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	10 interacting genes: ABCC8 AP1B1 CRYBA1 CRYBA2 CRYBA4 DDIT4L EXOC5 GAS8 TERF1 TERF2IP
Entrez ID		6833	1414
HPRD ID		02741	09021
Ensembl ID		ENSG00000006071	ENSG00000100122
Uniprot IDs		Q09428	P53674
PDB IDs		6C3O 6C3P	1OKI
Enriched GO Terms of Interacting Partners?
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