ENSA and ABCC8

Data Source:
HPRD (in vivo)

		ENSA	ABCC8
Description		endosulfine alpha	ATP binding cassette subfamily C member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Phosphatase Inhibitor Activity Potassium Channel Inhibitor Activity Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Nutrient Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Dephosphorylation Regulation Of Insulin Secretion Cell Division	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression	ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs			ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases			Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Albumin-globulin ratio ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Mean corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Morning person ( 30696823) Neutrophil percentage of granulocytes ( 27863252) Non-albumin protein levels ( 29403010) Pericardial adipose tissue adjusted for height and weight ( 27918534) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252) Urate levels ( 31578528)	Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		10 interacting genes: ABCC8 ACD ARIH2 ENO2 KCTD15 POT1 PSEN1 RAP2A SNCA SRPK2	5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		2029	6833
HPRD ID		11927	02741
Ensembl ID		ENSG00000143420	ENSG00000006071
Uniprot IDs		O43768	Q09428
PDB IDs			6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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