ABCC8 and KCNJ8

Data Source:
HPRD (in vitro)

		ABCC8	KCNJ8
Description		ATP binding cassette subfamily C member 8	potassium inwardly rectifying channel subfamily J member 8
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Inward Rectifying Potassium Channel Membrane Potassium Ion-transporting ATPase Complex	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Myofibril Potassium Ion-transporting ATPase Complex Sarcolemma
	Molecular Function	Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Ion Channel Binding	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Cation Transmembrane Transporter Activity Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport	Kidney Development Potassium Ion Transport Heart Development Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Response To Exogenous DsRNA Defense Response To Virus Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Transport Across Blood-brain Barrier Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels
Drugs		ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine	Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382)	Birth weight ( 31043758)
Interacting Genes		5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8	7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54
Entrez ID		6833	3764
HPRD ID		02741	02962
Ensembl ID		ENSG00000006071	ENSG00000121361
Uniprot IDs		Q09428	A0A024RAV6 Q15842
PDB IDs		6C3O 6C3P
Enriched GO Terms of Interacting Partners?
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