SPAST and RTN1

Data Source:
HPRD (in vivo, in vitro)

		SPAST	RTN1
Description		spastin	reticulon 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm	Golgi Membrane Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Axonogenesis Anterograde Axonal Transport Metabolic Process Exit From Mitosis Axonal Transport Of Mitochondrion Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Nuclear Envelope Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cytoskeleton-dependent Cytokinesis Membrane Fission	Negative Regulation Of Amyloid-beta Formation
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Broad depression or schizophrenia ( 30626913) Putamen volume ( 31530798) Schizophrenia ( 30285260)
Interacting Genes		4 interacting genes: CHMP1B IST1 RTN1 SSNA1	15 interacting genes: ADRB2 BCL2L1 CCR4 CHRM5 DRD2 F2RL1 FGFR1 FHIP1B HDAC8 LMNA NDRG1 PLEKHF2 SDCBP SPAST UGCG
Entrez ID		6683	6252
HPRD ID		05044	02921
Ensembl ID		ENSG00000021574	ENSG00000139970
Uniprot IDs		E5KRP5 E5KRP6 Q9UBP0	A8K3B9 Q16799
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN
Enriched GO Terms of Interacting Partners?
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