RTN1 and HDAC8

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RTN1	HDAC8
Description		reticulon 1	histone deacetylase 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding	Histone Deacetylase Activity Protein Binding Transcription Factor Binding Hsp70 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Amyloid-beta Formation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Assembly Or Disassembly Sister Chromatid Cohesion Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Loading
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs			Iron Zinc Vorinostat 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide Trichostatin A Belinostat Panobinostat (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE Coumarin 120 Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Broad depression or schizophrenia ( 30626913) Putamen volume ( 31530798) Schizophrenia ( 30285260)	Chloride levels ( 29403010) Sodium levels ( 29403010)
Interacting Genes		15 interacting genes: ADRB2 BCL2L1 CCR4 CHRM5 DRD2 F2RL1 FGFR1 FHIP1B HDAC8 LMNA NDRG1 PLEKHF2 SDCBP SPAST UGCG	9 interacting genes: ESRRA H3-4 H3C1 H4-16 H4C1 MDC1 PRKACA RTN1 RUNX1T1
Entrez ID		6252	55869
HPRD ID		02921	02227
Ensembl ID		ENSG00000139970	ENSG00000147099
Uniprot IDs		A8K3B9 Q16799	Q9BY41
PDB IDs			1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA6 4QA7 4RN0 4RN1 4RN2 5BWZ 5D1B 5D1C 5D1D 5DC5 5DC6 5DC7 5DC8 5FCW 5THS 5THT 5THU 5THV 5VI6 6HSK 6ODA 6ODB 6ODC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?