RTN1 and UGCG

Data Source:
HPRD (two hybrid, in vivo)

		RTN1	UGCG
Description		reticulon 1	UDP-glucose ceramide glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding Ceramide Glucosyltransferase Activity Dihydroceramide Glucosyltransferase Activity
	Biological Process	Negative Regulation Of Amyloid-beta Formation	Protein Lipidation Glucosylceramide Biosynthetic Process Glycosphingolipid Metabolic Process Epidermis Development Regulation Of Signal Transduction Cell Differentiation Keratinocyte Differentiation Leptin-mediated Signaling Pathway Neuron Development Establishment Of Skin Barrier Intestinal Lipid Absorption Cornified Envelope Assembly
Pathways			Glycosphingolipid metabolism
Drugs			Miglustat Eliglustat
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Broad depression or schizophrenia ( 30626913) Putamen volume ( 31530798) Schizophrenia ( 30285260)	Benign prostatic hyperplasia ( 30988330) Mean corpuscular hemoglobin ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		15 interacting genes: ADRB2 BCL2L1 CCR4 CHRM5 DRD2 F2RL1 FGFR1 FHIP1B HDAC8 LMNA NDRG1 PLEKHF2 SDCBP SPAST UGCG	3 interacting genes: APP RTN1 RTN3
Entrez ID		6252	7357
HPRD ID		02921	04190
Ensembl ID		ENSG00000139970	ENSG00000148154
Uniprot IDs		A8K3B9 Q16799	A0A024R157 Q16739
PDB IDs
Enriched GO Terms of Interacting Partners?
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