SNAI1 and PPIL2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, pull down)

		SNAI1	PPIL2
Description		snail family transcriptional repressor 1	peptidylprolyl isomerase like 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Golgi Lumen Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Protein Polyubiquitination Protein Peptidyl-prolyl Isomerization Protein Folding Leukocyte Migration Protein Localization To Plasma Membrane
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Basigin interactions
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Bipolar disorder ( 31043756) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926)
Interacting Genes		46 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CTDSP1 CTDSP2 CTDSPL EFHC1 EP300 EXOSC8 FBXO22 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIM50 TRIP6 USP17L2 USP3 USP37 XRCC3	8 interacting genes: APP BSG CALM1 CRNKL1 HSP90AA1 PRCC SNAI1 TRIM23
Entrez ID		6615	23759
HPRD ID		05025	08472
Ensembl ID		ENSG00000124216	ENSG00000100023
Uniprot IDs		O95863	A0A024R1C1 A8K0I0 Q13356
PDB IDs		2Y48 3W5K 3ZMT 4QLI	1ZKC
Enriched GO Terms of Interacting Partners?
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