SNAI1 and USP37

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SNAI1	USP37
Description		snail family transcriptional repressor 1	ubiquitin specific peptidase 37
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Protein K11-linked Deubiquitination Cell Division Protein K48-linked Deubiquitination
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Ub-specific processing proteases
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Body mass index ( 25673413) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Male-pattern baldness ( 28196072) Post bronchodilator FEV1/FVC ratio ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		46 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CTDSP1 CTDSP2 CTDSPL EFHC1 EP300 EXOSC8 FBXO22 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIM50 TRIP6 USP17L2 USP3 USP37 XRCC3	6 interacting genes: CCNA2 MYC RHOU SNAI1 UBC YWHAG
Entrez ID		6615	57695
HPRD ID		05025	07506
Ensembl ID		ENSG00000124216	ENSG00000135913
Uniprot IDs		O95863	A0A024R416 Q86T82
PDB IDs		2Y48 3W5K 3ZMT 4QLI	3U12
Enriched GO Terms of Interacting Partners?
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