SNAI1 and USP3

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		SNAI1	USP3
Description		snail family transcriptional repressor 1	ubiquitin specific peptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule Flemming Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle DNA Repair Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Ub-specific processing proteases
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Heart failure ( 20445134) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) LDL cholesterol levels ( 32203549) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum immune biomarker levels ( 32066700) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		46 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CTDSP1 CTDSP2 CTDSPL EFHC1 EP300 EXOSC8 FBXO22 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIM50 TRIP6 USP17L2 USP3 USP37 XRCC3	6 interacting genes: CHEK1 DDX58 IFIH1 SNAI1 TP53 UBC
Entrez ID		6615	9960
HPRD ID		05025	05290
Ensembl ID		ENSG00000124216	ENSG00000140455
Uniprot IDs		O95863	Q6JHV3 Q9Y6I4
PDB IDs		2Y48 3W5K 3ZMT 4QLI
Enriched GO Terms of Interacting Partners?
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