SNAI1 and FBXO22

Data Source:
BioGRID (enzymatic study)

		SNAI1	FBXO22
Description		snail family transcriptional repressor 1	F-box protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Cytosol Z Disc
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Skeletal Muscle Fiber Development
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Creatinine levels ( 29403010) Urate levels in obese individuals ( 25811787)
Interacting Genes		46 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CTDSP1 CTDSP2 CTDSPL EFHC1 EP300 EXOSC8 FBXO22 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIM50 TRIP6 USP17L2 USP3 USP37 XRCC3	1 interacting genes: SNAI1
Entrez ID		6615	26263
HPRD ID		05025	16437
Ensembl ID		ENSG00000124216	ENSG00000167196
Uniprot IDs		O95863	Q8NEZ5
PDB IDs		2Y48 3W5K 3ZMT 4QLI
Enriched GO Terms of Interacting Partners?
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