SKP1 and FBXO25

Data Source:
HPRD (in vivo)

		SKP1	FBXO25
Description		S-phase kinase associated protein 1	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Beta-catenin Binding Protein Domain Specific Binding Cullin Family Protein Binding F-box Domain Binding Ubiquitin Ligase-substrate Adaptor Activity	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Iron Ion Homeostasis SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Post-translational Protein Modification T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Maintenance Of Protein Location In Nucleus Interleukin-1-mediated Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Protein Ubiquitination
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Indoleacetic acid
Diseases
GWAS		Mean platelet volume ( 32888494) Systemic lupus erythematosus ( 27399966 26502338)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		80 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK2 CDK4 CDK9 CDKN1A CDKN1B CENPE CUL1 CUL7 DDX19B FBH1 FBXL14 FBXL2 FBXL20 FBXL22 FBXL3 FBXL4 FBXL5 FBXL6 FBXL8 FBXO11 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO27 FBXO28 FBXO3 FBXO32 FBXO34 FBXO4 FBXO43 FBXO44 FBXO46 FBXO48 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LAMTOR5 LMO2 MED21 MEOX2 MTUS1 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		6500	26260
HPRD ID		03255	16439
Ensembl ID		ENSG00000113558	ENSG00000147364
Uniprot IDs		P63208	A0A024QZ88 Q8TCJ0
PDB IDs		1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60 6TTU 6VCD 6W66 6WCQ 6WNX
Enriched GO Terms of Interacting Partners?
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