FBXO25 and RBM8A

Data Source:
BioGRID (enzymatic study)

		FBXO25	RBM8A
Description		F-box protein 25	RNA binding motif protein 8A
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	RNA Binding MRNA Binding Protein Binding
	Biological Process	Protein Ubiquitination	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus Regulation Of Translation RNA Splicing MRNA 3'-end Processing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	20 interacting genes: APP CDC42 DPH1 EIF4A3 FBXO25 IKBKG IPO13 KAT2B MAGOH MAGOHB MCM7 NXF1 RNPS1 SF3B2 SRPK1 SRPK2 TCF12 TOE1 UPF3A UPF3B
Entrez ID		26260	9939
HPRD ID		16439	05609
Ensembl ID		ENSG00000147364	ENSG00000265241
Uniprot IDs		A0A024QZ88 Q8TCJ0	A0A023T787 Q9Y5S9
PDB IDs			1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 5XJC 5YZG 6ICZ 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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