FBXO25 and NKX2-5

Data Source:
BioGRID (pull down, pull down)

		FBXO25	NKX2-5
Description		F-box protein 25	NK2 homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Septum Secundum Development Regulation Of Transcription By RNA Polymerase II Adult Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction
Pathways			YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Atrial septal defect Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) Ischemic stroke (cardioembolic) ( 29531354) PR interval ( 30046033 32439900 20062060) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	18 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10
Entrez ID		26260	1482
HPRD ID		16439	02787
Ensembl ID		ENSG00000147364	ENSG00000183072
Uniprot IDs		A0A024QZ88 Q8TCJ0	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs			3RKQ 4S0H 6WC2 6WC5
Enriched GO Terms of Interacting Partners?
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