RXRG and SRF

Data Source:
HPRD (two hybrid, in vivo)

		RXRG	SRF
Description		retinoid X receptor gamma	serum response factor
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Thymus Development Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long-term Synaptic Depression Face Development Heart Trabecula Formation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid	RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Etretinate Bezafibrate Phthalic Acid Doconexent
Diseases
GWAS		AIDS ( 19754311) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Macular thickness ( 30535121) Menarche (age at onset) ( 27182965 21102462 29773799 25231870) Metabolite levels ( 23823483) Personality traits in bipolar disorder ( 21368711) Proportion of activated microglia (midfrontal cortex) ( 30679421)
Interacting Genes		32 interacting genes: CAMK2B CEBPZ CHGB CKMT1A CKMT1B CREBBP DCK HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 PICK1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR	71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3
Entrez ID		6258	6722
HPRD ID		01579	02788
Ensembl ID		ENSG00000143171	ENSG00000112658
Uniprot IDs		A0A087WZ88 F1D8Q7 F1T097 P48443	A0A024RD16 B4DU24 P11831
PDB IDs		2GL8 7A79	1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?
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