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SRF and PRRX1
Data Source:
HPRD
(in vivo, in vitro)
SRF
PRRX1
Description
serum response factor
paired related homeobox 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Cytosol
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Chromatin DNA Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Primary MiRNA Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
HMG Box Domain Binding
Biological Process
Branching Involved In Blood Vessel Morphogenesis
Response To Hypoxia
Mesoderm Formation
Neuron Migration
Trophectodermal Cell Differentiation
Heart Looping
Morphogenesis Of An Epithelial Sheet
Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Cell-matrix Adhesion
Heart Development
Long-term Memory
Negative Regulation Of Cell Population Proliferation
Associative Learning
Response To Toxic Substance
Response To Hormone
Epithelial Structure Maintenance
Positive Regulation Of Transcription Via Serum Response Element Binding
Hippocampus Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Platelet Activation
Platelet Formation
Negative Regulation Of Cell Migration
Thyroid Gland Development
Neuron Projection Development
Regulation Of Water Loss Via Skin
Response To Cytokine
Megakaryocyte Development
Dorsal Aorta Morphogenesis
Stress Fiber Assembly
Skin Morphogenesis
Positive Thymic T Cell Selection
Sarcomere Organization
Positive Regulation Of Cell Differentiation
Positive Regulation Of Axon Extension
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Contraction
Positive Regulation Of Transcription By Glucose
Muscle Cell Cellular Homeostasis
Thymus Development
Developmental Growth
Neuron Development
Erythrocyte Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Filopodium Assembly
Cardiac Myofibril Assembly
Angiogenesis Involved In Wound Healing
Hematopoietic Stem Cell Differentiation
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Long-term Synaptic Depression
Face Development
Heart Trabecula Formation
Lung Morphogenesis
Bronchus Cartilage Development
Trachea Cartilage Development
Cardiac Vascular Smooth Muscle Cell Differentiation
Eyelid Development In Camera-type Eye
Lung Smooth Muscle Development
Bicellular Tight Junction Assembly
Cellular Response To Glucose Stimulus
Primitive Streak Formation
Epithelial Cell-cell Adhesion
Cellular Senescence
Negative Regulation Of Amyloid-beta Clearance
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mesenchymal Cell Proliferation
Regulation Of Transcription By RNA Polymerase II
Embryonic Limb Morphogenesis
Inner Ear Morphogenesis
Middle Ear Morphogenesis
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Neuron Fate Determination
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Cartilage Development
Roof Of Mouth Development
Regulation Of Neuron Projection Regeneration
Neuronal Stem Cell Population Maintenance
Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter
Pathways
RHO GTPases Activate Formins
NGF-stimulated transcription
NGF-stimulated transcription
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS
Atrial fibrillation (
28416818
28416822
29290336
29892015
22544366
)
Blood protein levels (
29875488
)
Calcific aortic valve stenosis (
32141789
)
Central corneal thickness (
32528159
)
Early onset atrial fibrillation (
28460022
)
Emphysema imaging phenotypes (
26030696
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Hip circumference adjusted for BMI (
28552196
25673412
)
Intraocular pressure (
29617998
)
Ischemic stroke (cardioembolic) (
29531354
)
Macular thickness (
30535121
)
Male-pattern baldness (
29146897
28196072
)
PR interval (
32439900
)
Prevalent atrial fibrillation (
28416818
)
Refractive error (
32231278
)
Response to angiotensin II receptor blocker therapy (
22566498
)
Systemic lupus erythematosus (
33536424
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
71 interacting genes:
ALDH3A1
ATF6
BARX2
CAMK2A
CASP3
CASP6
CASP7
CASP8
CASP9
CD63
CEBPB
CIRBP
CREB1
CREBBP
CRIP2
CSNK2A1
ELK1
ELK4
ETV4
FHL1
FHL2
FHL3
FHL5
FLI1
FOXG1
FOXK1
GATA4
GTF2F1
GTF2I
HDAC4
HMGA1
HOPX
KAT5
KDM6A
MAPKAPK2
MINPP1
MRTFA
MRTFB
MYOCD
MYOD1
MYOG
NCOA1
NCOA6
NCOR2
NFKB1
NFYA
NKX2-3
NKX2-5
NKX3-1
OGT
PML
PRKDC
PRRX1
PYCARD
RARA
REL
RELA
RPS6KA1
RXRA
RXRG
SHBG
SP1
SRC
SRFBP1
SSRP1
TCF3
TEAD1
TRIM63
TRIP4
UBE2I
ZIC3
8 interacting genes:
CINP
GTF2I
MAFF
MAFG
SAAL1
SOX10
SRF
SUOX
Entrez ID
6722
5396
HPRD ID
02788
01337
Ensembl ID
ENSG00000112658
ENSG00000116132
Uniprot IDs
A0A024RD16
B4DU24
P11831
P54821
PDB IDs
1HBX
1K6O
1SRS
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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