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SRF and MYOCD
Data Source:
HPRD
(in vitro, in vivo)
SRF
MYOCD
Description
serum response factor
myocardin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Chromatin
Nucleus
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Serum Response Element Binding
Chromatin DNA Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Primary MiRNA Binding
Sequence-specific Double-stranded DNA Binding
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Histone Deacetylase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
Biological Process
Branching Involved In Blood Vessel Morphogenesis
Response To Hypoxia
Mesoderm Formation
Neuron Migration
Trophectodermal Cell Differentiation
Heart Looping
Morphogenesis Of An Epithelial Sheet
Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Cell-matrix Adhesion
Heart Development
Long-term Memory
Negative Regulation Of Cell Population Proliferation
Associative Learning
Response To Toxic Substance
Response To Hormone
Epithelial Structure Maintenance
Positive Regulation Of Transcription Via Serum Response Element Binding
Hippocampus Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Platelet Activation
Platelet Formation
Negative Regulation Of Cell Migration
Thyroid Gland Development
Neuron Projection Development
Regulation Of Water Loss Via Skin
Response To Cytokine
Megakaryocyte Development
Dorsal Aorta Morphogenesis
Stress Fiber Assembly
Skin Morphogenesis
Positive Thymic T Cell Selection
Sarcomere Organization
Positive Regulation Of Cell Differentiation
Positive Regulation Of Axon Extension
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Contraction
Positive Regulation Of Transcription By Glucose
Muscle Cell Cellular Homeostasis
Thymus Development
Developmental Growth
Neuron Development
Erythrocyte Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Filopodium Assembly
Cardiac Myofibril Assembly
Angiogenesis Involved In Wound Healing
Hematopoietic Stem Cell Differentiation
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Long-term Synaptic Depression
Face Development
Heart Trabecula Formation
Lung Morphogenesis
Bronchus Cartilage Development
Trachea Cartilage Development
Cardiac Vascular Smooth Muscle Cell Differentiation
Eyelid Development In Camera-type Eye
Lung Smooth Muscle Development
Bicellular Tight Junction Assembly
Cellular Response To Glucose Stimulus
Primitive Streak Formation
Epithelial Cell-cell Adhesion
Cellular Senescence
Negative Regulation Of Amyloid-beta Clearance
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth By Extracellular Stimulus
Vasculogenesis
Response To Hypoxia
Cardiac Ventricle Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Myotube Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cardiocyte Differentiation
Regulation Of Histone Acetylation
Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of DNA Binding
Cellular Component Maintenance
Regulation Of Myoblast Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Contraction
Lung Alveolus Development
Digestive Tract Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Smooth Muscle Cell Differentiation
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell Differentiation
Cardiac Muscle Cell Differentiation
Ventricular Cardiac Muscle Cell Differentiation
Uterus Development
Urinary Bladder Development
Negative Regulation Of Cell Adhesion Molecule Production
Ductus Arteriosus Closure
Negative Regulation Of Amyloid-beta Clearance
Regulation Of Phenotypic Switching
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Differentiation
Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways
RHO GTPases Activate Formins
NGF-stimulated transcription
NGF-stimulated transcription
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS
Atrial fibrillation (
30061737
29892015
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Metabolite levels (
23823483
)
PR interval (
30679814
30046033
32439900
)
QRS duration (
31251759
)
Systolic blood pressure change trajectories (
27980656
)
Testosterone levels (
22675492
)
Interacting Genes
71 interacting genes:
ALDH3A1
ATF6
BARX2
CAMK2A
CASP3
CASP6
CASP7
CASP8
CASP9
CD63
CEBPB
CIRBP
CREB1
CREBBP
CRIP2
CSNK2A1
ELK1
ELK4
ETV4
FHL1
FHL2
FHL3
FHL5
FLI1
FOXG1
FOXK1
GATA4
GTF2F1
GTF2I
HDAC4
HMGA1
HOPX
KAT5
KDM6A
MAPKAPK2
MINPP1
MRTFA
MRTFB
MYOCD
MYOD1
MYOG
NCOA1
NCOA6
NCOR2
NFKB1
NFYA
NKX2-3
NKX2-5
NKX3-1
OGT
PML
PRKDC
PRRX1
PYCARD
RARA
REL
RELA
RPS6KA1
RXRA
RXRG
SHBG
SP1
SRC
SRFBP1
SSRP1
TCF3
TEAD1
TRIM63
TRIP4
UBE2I
ZIC3
11 interacting genes:
GOPC
GSK3B
KDM3A
MAMSTR
MRTFA
MYOD1
SMAD2
SMAD3
SMARCA4
SRF
STUB1
Entrez ID
6722
93649
HPRD ID
02788
09362
Ensembl ID
ENSG00000112658
ENSG00000141052
Uniprot IDs
A0A024RD16
B4DU24
P11831
Q8IZQ8
PDB IDs
1HBX
1K6O
1SRS
Enriched GO Terms of Interacting Partners
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