ROBO2 and CENPU

Data Source:
BioGRID (two hybrid)

		ROBO2	CENPU
Description		roundabout guidance receptor 2	centromere protein U
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Axolemma Extracellular Exosome	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Protein Binding
	Biological Process	Metanephros Development Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development
Pathways		Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Vesicoureteral reflux
GWAS		Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4	17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		6092	79682
HPRD ID		11895	14722
Ensembl ID		ENSG00000185008	ENSG00000151725
Uniprot IDs		Q9HCK4	Q71F23
PDB IDs		1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?
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