ROBO2 and OLFM2

Data Source:
HPRD (two hybrid)

		ROBO2	OLFM2
Description		roundabout guidance receptor 2	olfactomedin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Axolemma Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm AMPA Glutamate Receptor Complex Synapse
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding	Protein Binding
	Biological Process	Metanephros Development Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis	Protein Secretion Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Pathways		Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5
Drugs
Diseases		Vesicoureteral reflux
GWAS		Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)	Blood protein levels ( 30072576) Menarche (age at onset) ( 27182965 21102462 25231870) Sleep duration ( 30531941)
Interacting Genes		18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4	14 interacting genes: BLOC1S6 EIF1 FANCF GNB5 KRTAP1-3 KRTAP10-3 NBAS NBPF19 NOTCH2NLA PKM ROBO2 RPS6 SRSF5 ST13
Entrez ID		6092	93145
HPRD ID		11895	10127
Ensembl ID		ENSG00000185008	ENSG00000105088
Uniprot IDs		Q9HCK4	K7EIS8 O95897
PDB IDs		1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?
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