HRH4 and GNA15

Data Source:
HPRD (in vivo)

		HRH4	GNA15
Description		histamine receptor H4	G protein subunit alpha 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Heterotrimeric G-protein Complex Plasma Membrane Synapse
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Action Potential G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Histamine receptors G alpha (i) signalling events	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Response to taxane treatment (docetaxel) ( 23006423)	Asthma ( 31959851 32296059) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: CCL16 GNA15 GNAI1 GNAO1	19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		59340	2769
HPRD ID		06004	00760
Ensembl ID		ENSG00000134489	ENSG00000060558
Uniprot IDs		B2KJ49 Q9H3N8	P30679
PDB IDs
Enriched GO Terms of Interacting Partners?
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