GNA15 and CNR1

Data Source:
HPRD (in vivo)

		GNA15	CNR1
Description		G protein subunit alpha 15	cannabinoid receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Cytoplasm Mitochondrial Outer Membrane Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Growth Cone Integral Component Of Mitochondrial Membrane Membrane Raft Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Drug Binding Identical Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Action Potential G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Negative Regulation Of Serotonin Secretion Regulation Of Metabolic Process Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection Retrograde Trans-synaptic Signaling By Endocannabinoid Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Dronabinol Nabilone Ricinoleic Acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Asthma ( 31959851 32296059) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	8 interacting genes: GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Entrez ID		2769	1268
HPRD ID		00760	00259
Ensembl ID		ENSG00000060558	ENSG00000118432
Uniprot IDs		P30679	P21554 S5TLS4 V5KA96
PDB IDs			1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B
Enriched GO Terms of Interacting Partners?
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