HRH4 and CCL16

Data Source:
HPRD (in vivo)

		HRH4	CCL16
Description		histamine receptor H4	C-C motif chemokine ligand 16
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Extracellular Region Extracellular Space
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	Protein Binding Chemokine Activity Chemoattractant Activity CCR Chemokine Receptor Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Monocyte Chemotaxis Chemotaxis Inflammatory Response Cell Communication G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Positive Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Histamine receptors G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
Diseases
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Response to taxane treatment (docetaxel) ( 23006423)	Blood protein levels ( 29875488 28240269) Initial pursuit acceleration ( 29064472)
Interacting Genes		4 interacting genes: CCL16 GNA15 GNAI1 GNAO1	6 interacting genes: CCL5 CCR1 CCR5 CCR8 HRH4 UBQLN2
Entrez ID		59340	6360
HPRD ID		06004	03233
Ensembl ID		ENSG00000134489	ENSG00000275152
Uniprot IDs		B2KJ49 Q9H3N8	O15467
PDB IDs			5LTL
Enriched GO Terms of Interacting Partners?
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