GNA15 and GRM4

Data Source:
HPRD (in vivo)

		GNA15	GRM4
Description		G protein subunit alpha 15	glutamate metabotropic receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Presynapse
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Action Potential G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway	Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Glutamic acid
Diseases
GWAS		Asthma ( 31959851 32296059) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) BMI at birth ( 31575865) Body mass index ( 26426971 28892062) Childhood body mass index ( 33045005) Inflammatory skin disease ( 25574825) Osteosarcoma ( 23727862) Pulse pressure ( 30578418) Regular attendance at a gym or sports club ( 29970889) Tonsillectomy ( 27182965 28928442) Uterine fibroids ( 31649266)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	4 interacting genes: CALM1 FLNA GNA15 GNAQ
Entrez ID		2769	2914
HPRD ID		00760	04978
Ensembl ID		ENSG00000060558	ENSG00000124493
Uniprot IDs		P30679	A1L4F9 A8K0J8 B7ZLU9 Q14833
PDB IDs
Enriched GO Terms of Interacting Partners?
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