RAP1GAP and RALGDS

Data Source:
HPRD (in vitro)

		RAP1GAP	RALGDS
Description		RAP1 GTPase activating protein	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Membrane	Nucleus Cytosol Brush Border
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Axon Guidance Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Rap1 signalling RET signaling	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		15 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		5909	5900
HPRD ID		02609	03371
Ensembl ID		ENSG00000076864	ENSG00000160271
Uniprot IDs		A0A024RAB5 P47736 X6R8W7	Q12967 Q8N4Y1
PDB IDs		1SRQ 3BRW	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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