RAP1GAP and AFDN

Data Source:
HPRD (in vitro, two hybrid)

		RAP1GAP	AFDN
Description		RAP1 GTPase activating protein	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Membrane	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Signal Transduction Axon Guidance Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Rap1 signalling RET signaling
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		15 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		5909	4301
HPRD ID		02609	01164
Ensembl ID		ENSG00000076864	ENSG00000130396
Uniprot IDs		A0A024RAB5 P47736 X6R8W7	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		1SRQ 3BRW	1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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