RALGDS and CNKSR1

Data Source:
HPRD (in vivo)

		RALGDS	CNKSR1
Description		ral guanine nucleotide dissociation stimulator	connector enhancer of kinase suppressor of Ras 1
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GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Ras Protein Signal Transduction Regulation Of Catalytic Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		5900	10256
HPRD ID		03371	11937
Ensembl ID		ENSG00000160271	ENSG00000142675
Uniprot IDs		Q12967 Q8N4Y1	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		1RAX 2B3A 2RGF 3KH0	1WWV
Enriched GO Terms of Interacting Partners?
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