PEX5 and AGXT

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		PEX5	AGXT
Description		peroxisomal biogenesis factor 5	alanine--glyoxylate and serine--pyruvate aminotransferase
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex	Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding Protein Sequestering Activity	Serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity Protein Self-association
	Biological Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Protein Import Into Peroxisome Membrane	Protein Targeting To Peroxisome Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Glyoxylate Metabolic Process Response To Glucocorticoid Response To CAMP
Pathways		Pexophagy	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs			Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Primary hyperoxaluria (HP)
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)	Blood metabolite levels ( 24816252) Height ( 25282103 31562340) Urinary metabolites ( 26352407)
Interacting Genes		76 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	39 interacting genes: ACAT1 ATXN1L BATF3 C11orf1 C19orf54 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19
Entrez ID		5830	189
HPRD ID		02684	05048
Ensembl ID		ENSG00000139197	ENSG00000172482
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	P21549
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO	1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1
Enriched GO Terms of Interacting Partners?
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