PEX5 and ACOX2

Data Source:
BioGRID (unspecified method)

		PEX5	ACOX2
Description		peroxisomal biogenesis factor 5	acyl-CoA oxidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex	Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding Protein Sequestering Activity	Acyl-CoA Oxidase Activity Fatty Acid Binding Protein Binding Palmitoyl-CoA Oxidase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase Activity Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Protein Import Into Peroxisome Membrane	Very Long-chain Fatty Acid Metabolic Process Protein Targeting To Peroxisome Bile Acid Biosynthetic Process Positive Regulation Of Cell Death Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Lipid Homeostasis Positive Regulation Of Response To Oxidative Stress
Pathways		Pexophagy	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Beta-oxidation of pristanoyl-CoA Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)	Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 28714469)
Interacting Genes		76 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	3 interacting genes: CLK1 DYNLT1 PEX5
Entrez ID		5830	8309
HPRD ID		02684	09037
Ensembl ID		ENSG00000139197	ENSG00000168306
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	Q99424
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO
Enriched GO Terms of Interacting Partners?
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