AGXT and ACAT1

Data Source:
BioGRID (two hybrid)

		AGXT	ACAT1
Description		alanine--glyoxylate and serine--pyruvate aminotransferase	acetyl-CoA acetyltransferase 1
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GO Annotations	Cellular Component	Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	Serine-pyruvate Transaminase Activity Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity Protein Self-association	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Potassium Ion Binding
	Biological Process	Protein Targeting To Peroxisome Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Glyoxylate Metabolic Process Response To Glucocorticoid Response To CAMP	Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Acetyl-CoA Catabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process
Pathways		Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import	Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies
Drugs		Pyridoxal phosphate Serine Glycine Alanine Aminooxyacetic acid N(6)-(pyridoxal phosphate)-L-lysine 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID	Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases		Primary hyperoxaluria (HP)
GWAS		Blood metabolite levels ( 24816252) Height ( 25282103 31562340) Urinary metabolites ( 26352407)	Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ACAT1 ATXN1L BATF3 C11orf1 C19orf54 CHIC2 CYSRT1 EFS FAM168B FHL5 FNTB FOSB GLP1R HOXA1 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP12-3 KRTAP3-1 KRTAP6-3 KRTAP8-1 KRTAP9-2 LPXN MDFI MORN5 NBPF19 NOTCH2NLA OIP5 PEX5 PLA2G10 PRDM6 PRICKLE4 RFX6 SNCAIP SPRYD7 TRAPPC14 TTC19	4 interacting genes: AGXT PDP1 PEX7 PTPRF
Entrez ID		189	38
HPRD ID		05048	01946
Ensembl ID		ENSG00000172482	ENSG00000075239
Uniprot IDs		P21549	A0A140VJX1 A0A5F9ZHJ0 P24752
PDB IDs		1H0C 1J04 2YOB 3R9A 4CBR 4CBS 4I8A 4KXK 4KYO 5F9S 5HHY 5LUC 5OFY 5OG0 6RV0 6RV1	2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
Enriched GO Terms of Interacting Partners?
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