PEX5 and HMGCL

Data Source:
BioGRID (unspecified method)

		PEX5	HMGCL
Description		peroxisomal biogenesis factor 5	3-hydroxy-3-methylglutaryl-CoA lyase
Image
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding Protein Sequestering Activity	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding
	Biological Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Protein Import Into Peroxisome Membrane	Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid
Pathways		Pexophagy	Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs			3-hydroxyglutaric acid
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)	High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		76 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126
Entrez ID		5830	3155
HPRD ID		02684	02003
Ensembl ID		ENSG00000139197	ENSG00000117305
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	P35914
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO	2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?