LRRC7 and CDH2

Data Source:
HPRD (in vitro, in vivo)

		LRRC7	CDH2
Description		leucine rich repeat containing 7	cadherin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Centrosome Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Specific Granule Lumen Axon Initial Segment	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Collagen-containing Extracellular Matrix Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding
	Biological Process	MAPK Cascade Embryo Development Positive Regulation Of Neuron Projection Development Receptor Clustering Neutrophil Degranulation Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity	Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Brain Development Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Regulation Of Axonogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 21784300) Body mass index ( 24348519) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666) Psoriasis ( 25939698) Type 2 diabetes ( 31049640)	Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)
Interacting Genes		17 interacting genes: ACTN2 ACTN4 ADGRB1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 EPS15L1 ERBB2 ERBB3 ERBB4 HOMER3 HOMEZ NQO2 PPP1R9B TOR1A	23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC
Entrez ID		57554	1000
HPRD ID		09930	00226
Ensembl ID		ENSG00000033122	ENSG00000170558
Uniprot IDs		A0A075B6E9	A0A024RC42 C9J126 P19022
PDB IDs
Enriched GO Terms of Interacting Partners?
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