CDH2 and CDH4

Data Source:
HPRD (in vivo)

		CDH2	CDH4
Description		cadherin 2	cadherin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Collagen-containing Extracellular Matrix Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integral Component Of Plasma Membrane Catenin Complex
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding	Calcium Ion Binding Cadherin Binding
	Biological Process	Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Brain Development Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Regulation Of Axonogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Adherens Junction Organization Positive Regulation Of Axon Extension Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation	Adherens junctions interactions Myogenesis Myogenesis
Drugs
Diseases
GWAS		Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) 3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Axial length ( 24144296) Cerebrospinal T-tau levels ( 20932310) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Fish intake frequency ( 31320941) General cognitive ability ( 29844566) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Longevity ( 20834067) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Sudden cardiac arrest ( 21658281) Volumetric brain MRI ( 17903297)
Interacting Genes		23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC	3 interacting genes: CDH2 MTNR1B UBE2I
Entrez ID		1000	1002
HPRD ID		00226	04304
Ensembl ID		ENSG00000170558	ENSG00000179242
Uniprot IDs		A0A024RC42 C9J126 P19022	P55283
PDB IDs
Enriched GO Terms of Interacting Partners?
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