CDH2 and CDH11

Data Source:
HPRD (in vivo)

		CDH2	CDH11
Description		cadherin 2	cadherin 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell Surface Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Sarcolemma Neuron Projection Plasma Membrane Raft Apical Part Of Cell Collagen-containing Extracellular Matrix Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Specialization Membrane	Cytoplasm Plasma Membrane Adherens Junction Integral Component Of Membrane Catenin Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding	Calcium Ion Binding Cadherin Binding
	Biological Process	Type B Pancreatic Cell Development Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Assembly Brain Development Glial Cell Differentiation Neural Crest Cell Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebral Cortex Development Adherens Junction Organization Detection Of Muscle Stretch Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Cell-cell Adhesion Mediated By Cadherin Blood Vessel Morphogenesis Brain Morphogenesis Homeostasis Of Number Of Cells Regulation Of Axonogenesis Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Radial Glial Cell Differentiation Neuroepithelial Cell Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Migration Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering	Cell Morphogenesis Skeletal System Development Ossification Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Corticospinal Tract Morphogenesis Adherens Junction Organization Modulation Of Chemical Synaptic Transmission Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Adherens junctions interactions Myogenesis Myogenesis Post-translational protein phosphorylation	Adherens junctions interactions
Drugs			Celecoxib
Diseases
GWAS		Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Periodontal disease-related phenotype (Socransky) ( 24347629) PR interval ( 32439900) Refractive error ( 32231278) Response to hepatitis B vaccine ( 29534301) Resting heart rate ( 27798624) Temperament (bipolar disorder) ( 22365631) Type 2 diabetes ( 31049640) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) vWF and FVIII levels ( 21810271)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 26252872) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Deep white matter hyperintensities ( 32517579) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 30054594) Hand grip strength ( 29691431) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lung cancer in never smokers ( 28604730) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Schizophrenia ( 28991256) Systolic blood pressure ( 27841878) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		23 interacting genes: ARHGAP32 ARVCF BOC CDH11 CDH4 CDON CREBBP CTNNA1 CTNNB1 CTNND2 EXOC5 FGFR4 GNA12 GNA13 GRIK2 GRIN1 GRIN2D JUP LRRC7 PIK3R1 PKP4 PTPN1 UBC	3 interacting genes: CDH2 CTNNB1 MTNR1B
Entrez ID		1000	1009
HPRD ID		00226	08960
Ensembl ID		ENSG00000170558	ENSG00000140937
Uniprot IDs		A0A024RC42 C9J126 P19022	H3BUU9 P55287
PDB IDs
Enriched GO Terms of Interacting Partners?
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