SCYL1 and CDC25A

Data Source:
BioGRID (two hybrid)

		SCYL1	CDC25A
Description		SCY1 like pseudokinase 1	cell division cycle 25A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Microtubule Organizing Center Cytosol Membrane COPI Vesicle Coat	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Tyrosine Kinase Activity ATP Binding Cadherin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding Chaperone Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Inflammatory Response Peptidyl-tyrosine Phosphorylation Spinal Cord Motor Neuron Differentiation Cellular Protein Localization Neuron Development	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways			Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Grn163l
Diseases
GWAS		Acne (severe) ( 24927181) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femoral neck bone mineral density ( 22504420) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946)	Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Loneliness (multivariate analysis) ( 27629369) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447)
Interacting Genes		23 interacting genes: APP ARCN1 ARF1 ARF3 AXIN1 CCNF CD93 CDC25A CHD1L COIL COPA COPB1 COPE COPG1 DAPK1 DDX6 GORAB LENG1 NOD2 PIN1 PLEKHF2 SMURF1 TCEA2	56 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		57410	993
HPRD ID		06414	00305
Ensembl ID		ENSG00000142186	ENSG00000164045
Uniprot IDs		E9PK59 Q96KG9	A0A024R2R6 D8KXX0 K7N7S0 P30304
PDB IDs			1C25
Enriched GO Terms of Interacting Partners?
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