CDC25A and FGF21

Data Source:
BioGRID (two hybrid)

		CDC25A	FGF21
Description		cell division cycle 25A	fibroblast growth factor 21
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding Chaperone Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle	Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Triglyceride Catabolic Process Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Cell Differentiation Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Cellular Response To Drug Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Endothelial Cell Apoptotic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Methionine Positive Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Cellular hexose transport Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Loneliness (multivariate analysis) ( 27629369) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447)	Bipolar disorder ( 21926972) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Cooked vegetable consumption ( 32066663) Dietary macronutrient intake ( 23372041 23636237 29988085) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Relative carbohydrate intake ( 32393786) Relative protein intake ( 32393786) Relative sugar intake ( 32393786) Resting metabolic rate ( 28476931) Retinal vascular caliber ( 21060863) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Urinary sodium excretion ( 31409800)
Interacting Genes		56 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	9 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 SGTA SGTB TNS2 YPEL3
Entrez ID		993	26291
HPRD ID		00305	09447
Ensembl ID		ENSG00000164045	ENSG00000105550
Uniprot IDs		A0A024R2R6 D8KXX0 K7N7S0 P30304	Q9NSA1
PDB IDs		1C25	5VAQ
Enriched GO Terms of Interacting Partners?
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