TRIM39 and CACTIN

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		TRIM39	CACTIN
Description		tripartite motif containing 39	cactin, spliceosome C complex subunit
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Multicellular Organism Development Regulation Of Gene Expression Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	4 interacting genes: CLK2 HMGB2 NELFE TRIM39
Entrez ID		56658	58509
HPRD ID		09298	18930
Ensembl ID		ENSG00000204599	ENSG00000105298
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	Q8WUQ7
PDB IDs		2DID 2DIF 2ECJ	6QDV
Enriched GO Terms of Interacting Partners?
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