CACTIN and NELFE

Data Source:
BioGRID (two hybrid)

		CACTIN	NELFE
Description		cactin, spliceosome C complex subunit	negative elongation factor complex member E
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Plasma Membrane Nuclear Body NELF Complex
	Molecular Function	RNA Binding Protein Binding	Chromatin Binding RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Multicellular Organism Development Regulation Of Gene Expression Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of MRNA Polyadenylation
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) vWF levels ( 30586737)
Interacting Genes		4 interacting genes: CLK2 HMGB2 NELFE TRIM39	10 interacting genes: CACTIN CCDC57 MTUS2 NCOR1 NELFB SRPK1 SRPK2 TNKS TRIM27 VAMP3
Entrez ID		58509	7936
HPRD ID		18930	01096
Ensembl ID		ENSG00000105298	ENSG00000204356
Uniprot IDs		Q8WUQ7	A0A1U9X830 P18615
PDB IDs		6QDV	1X5P 2BZ2 2JX2 5OOB 6GML
Enriched GO Terms of Interacting Partners?
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